Digest: Novikova 2011 — Ultrasound Therapy in Glaucoma
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Clinical takeaway: In 157 treated vs 49 control eyes, feedback‑guided 9bio-regulated) , low‑intensity ocular ultrasound yielded greater gains in aqueous outflow and optic‑nerve function indices than conventional ultrasound.
Summary: This trial tested low-intensity ocular ultrasound, tuned by physiologic feedback (bio-regulation). Compared with conventional low intensity ultrasound, it yielded bigger improvements in outflow facility, IOP, and optic‑nerve electrophysiology, with advantages persisting at follow‑up (≈6 months in early POAG; ≈4 months in advanced POAG).
For clinicians, this points to ultrasound as a plausible adjunct for outflow and nerve support, beyond diagnostic use.
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Data & Methods
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Design & Population: 160 patients (206 eyes): 157 bio regulated ultrasound treated, 49 controls (low intensity ultrasound); POAG, stages I–II.
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Intervention: Low-intensity ocular ultrasound therapy with biocontrol (dose modulation based on physiologic feedback). Comparator: the same ultrasound without feedback.
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Protocol: 7 sessions, 10 minutes each.
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Outcomes:
- Hydrodynamics: significant ↑ in aqueous outflow coefficient.
- Optic nerve function: improved in ~75% treated vs 40% control.
- IOP reduction: more pronounced and sustained in treated group.
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Notes: Bio-regulated ultrasound produced 2–3× greater functional gains than standard ultrasound.
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