Digest: Sidelnikova 2014 — Laser‑Magnetic Stimulation in Glaucoma
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Clinical takeaway: In 190 glaucomatous eyes (96 treated vs 94 control), low-intensity infrared laser paired with a weak magnetic field, targeted to the trabecular/drainage region, produced expanded fields, reduced scotomas, and improved ciliary artery blood flow and lower IOP.
Summary:
Researchers combined low-intensity infrared laser with a weak magnetic field, targeted dynamically to the trabecular drainage region. This approach produced a dual effect—field expansion, scotoma reduction, improved ocular hemodynamics, better electrophysiology, and lowered intraocular pressure with improved outflow coefficient. Effects were most pronounced in early/moderate POAG and remained stable for 3 months, supporting its role as an adjunct when fields are narrowing despite standard care.
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Data & Methods
- Design & Population: 126 patients with POAG (190 eyes: 96 treated, 94 controls).
- Intervention: Dynamic IR laser (850 nm, 3.5 mW) + weak alternating magnetic field (20 mT), directed transpalpebrally at trabecular meshwork.
- Protocol: 10 daily sessions, 10 minutes each.
- Outcomes:
- Visual fields: 52% reduction in scotomas; some absolute → relative.
- IOP & Outflow: true IOP ↓ 3–5 mmHg; outflow coefficient ↑, esp. Stages I–II.
- Electrophysiology: VEP amplitude ↑ ~15% (early/moderate); latency ↓ 15% (Stage I).
- Hemodynamics (SPCA): systolic velocity ↑ ~15%; diastolic ↑ ~20% (early/moderate); resistance index ↓.
- Notes: Most effective in early/moderate glaucoma; safe, well tolerated; benefits persisted for 3 months.
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