Digest: Kamenskikh 2015 — Comparative Low-Intensity Device Therapies in Glaucoma

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Clinical takeaway: In 634 glaucomatous eyes, transcranial magnetic stimulation — either alone, combined with electrostimulation, or applied to cervical sympathetic ganglia — produced measurable gains in visual fields, stronger VEPs, and improved ocular blood flow.

Summary:
This trial compared three non-invasive regimens:

  1. Magnetotherapy alone
  2. Magnet + electrostimulation
  3. Magnet at cervical sympathetic ganglia

All groups improved, with Group 2 showing the strongest functional and electrophysiological gains, and Group 3 showing the most pronounced vascular improvements. Together, results confirm that magnet-based approaches can improve conduction and perfusion in POAG.

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Data & Methods

  • Design & Population: 397 patients (634 eyes) with POAG, stages I–III.

  • Interventions:

    • Group 1: (182 eyes) Transcranial magnetotherapy
    • Group 2: (258 eyes) Transcranial magnetotherapy + electrostimulation
    • Group 3: (194 eyes) Magnetotherapy of cervical sympathetic ganglia
  • Protocol: 10 daily sessions, 20 min each.

  • Outcomes:

    • Visual fields: Expansion with scotoma reduction in up to 65% of Group 2, ~30% of Group 3
    • Electrophysiology: P100 amplitude ↑ 25–35%; latency ↓ 5–10 ms.
    • Hemodynamics (PSCA):
      • systolic velocity ↑ 15–30%;
      • diastolic velocity ↑ up to ~80%;
      • resistance index ↓ 15–35%.
  • Notes: Group 2 gave the strongest visual/functional gains, while Group 3 gave the greatest vascular improvements.


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