Digest: Baranov 2016 — Multi-Modal Non-Invasive Stimulation Across Optic-Nerve Disorders
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Clinical takeaway: In 443 eyes with partial optic nerve atrophy and 157 eyes with retinal dystrophies, laser, electrostimulation, and millimeter-wave therapy — synchronized to patient biorhythms — produced significant, lasting improvements in acuity and fields, far surpassing results from older, non-synchronized devices, confirmed at long-term follow-up.
Summary:
Across glaucomatous, vascular, traumatic, toxic, and infectious optic-nerve cases, the pattern was consistent: coordinated, low-intensity modalities stabilize and restore function more effectively than traditional methods.
The standout finding is durability: unlike many short-term interventions, these improvements were stable months later. For clinicians, this points to the potential of coordinated, low-intensity modalities to stabilize or even restore optic-nerve function.
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Data & Methods
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Design & Population: 294 patients (443 eyes) with partial optic nerve atrophy (PONA); 90 patients (157 eyes) with retinal dystrophies (CCRD, PRA).
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Etiologies: Glaucoma (201 eyes), vascular (88), post-traumatic (62), toxic (19), neuroinfection (9), unidentified (64).
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Interventions: Biocontrolled therapy using:
- Electrostimulation (transcutaneous).
- Laser therapy (low-intensity).
- Millimeter-wave (MMW) therapy. All synchronized to patient biorhythms (pulse/respiration)
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Protocol: 10–12 sessions
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Outcomes:
- Visual acuity: ↑ 0.07–0.18 in 75–95% of eyes.
- Visual fields: expanded 27–42° in 82–94%.
- Follow-up: 40–50% showed further gains months later; control group often declined.
- Relative efficacy: Gains were 1.5–3.5× greater than with non-synchronized device treatments.
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Notes: In retinal dystrophies, biocontrolled electrostimulation was most effective (94.7% improved). CCRD and PRA both benefited, with sustained gains up to 12 months.
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